Hyperosmolar Hyperglycemic State (HHS)

What is HHS?

HHS is a life-threatening complication of diabetes characterized by extremely high blood sugar (often >600 mg/dL) and severe dehydration, but WITHOUT ketones (unlike DKA).

Who gets it?

Primarily older adults with Type 2 Diabetes. It develops slowly over days to weeks.

Triggers:

  • Infection (pneumonia, UTI).
  • Illness or stress.
  • Not drinking enough fluids.
  • Certain medications (steroids, diuretics).

Symptoms:

  • Extreme thirst and dry mouth.
  • Frequent urination (eventually stops when severely dehydrated).
  • Weakness, confusion, or altered mental state.
  • Seizures or coma.
  • NO fruity breath (no ketones).

Why is itdangerous?

The blood becomes "syrup-like" from extreme sugar concentration. This can cause blood clots (stroke, heart attack) and organ failure. Mortality rate is 10-20%.

Treatment:

Requires ICU admission.

  • Massive IV Fluids: The priority is rehydration.
  • IV Insulin: To gradually lower blood sugar (must be done slowly to avoid brain swelling).
  • Electrolytes: Replacing potassium and sodium.

Prevention:

  • Monitor blood sugar during illness.
  • Stay hydrated (especially in hot weather or when sick).
  • Seek medical attention if blood sugar is consistently >300 mg/dL.

Resources: